Sökning: "TLRs"
Visar resultat 6 - 10 av 50 avhandlingar innehållade ordet TLRs.
6. Role of Toll-like receptors in airway inflammation
Sammanfattning : Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. LÄS MER
7. Innate immunity atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide
Sammanfattning : Atherosclerosis, a disease characterized by fibroinflammatory lipid lesions in the arterial wall, is the leading cause of mortality in the Western world. For decades research has been aimed at dissecting the pathogenesis of this multifactorial disease. LÄS MER
8. Clinical and pathogenic aspects of otitis media
Sammanfattning : One study on clinical treatment strategies in otitis media and two studies elucidating immunological events in otitis media in vitro, were conducted and joined in this thesis. First, topical treatment with or without systemic antibiotics against tube associated otorrhea in children with recurrent acute otitis media was evaluated. LÄS MER
9. Characterization of host and microbe interactions affecting adherence, clearance and systemic spread of S. pneumoniae
Sammanfattning : Streptococcus pneumoniae (the pneumococcus) mainly gives rise to diseases of the respiratory tract, such as pneumonia, acute otitis media and sinusitis, but it also causes severe invasive diseases, such as meningitis and sepsis. The pneumococcus accounts for approximately two million deaths world-wide every year, the majority of which are children in developing countries. LÄS MER
10. Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
Sammanfattning : Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammatory cytokines and type-I interferons. LÄS MER