Sökning: "TLR"

Visar resultat 1 - 5 av 107 avhandlingar innehållade ordet TLR.

  1. 1. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 2. Dysregulated mucosal immune responses in microscopic colitis patients

    Författare :Sezin Günaltay; Elisabeth Hultgren-Hörnquist; Olof Hultgren; Nils Nyhlin; Allan Mowat; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microscopic colitis; collagenous colitis; lymphocytic colitis; TLR; chemokine; chemokine receptor; IL-37; TCR; Immunologi; Immunology; Biomedicin; Biomedicine;

    Sammanfattning : Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC) is a common cause of chronic watery diarrhea. The diagnosis relies on typical histopathological changes observed upon microscopic examination. LÄS MER

  4. 3. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes

    Författare :Sara Tengvall; Göteborgs universitet; []
    Nyckelord :female genital tract immunity; genital herpes; mucosal adjuvant; TLR; MyD88; CpG ODN;

    Sammanfattning : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. LÄS MER

  5. 4. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents

    Författare :Sandra Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; TNF; TLR; dectin-1; lipid rafts; Src; Btk; Macrophages; arachidonate;

    Sammanfattning : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. LÄS MER

  7. 5. Novel actions of thrombin-derived host defense peptides

    Författare :Finja Hansen; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host defense peptides; Thrombin; Monocytes Macrophages; Gram-negative bacteria; LPS; TLR; Phagocytosis; Inflammation; Endocytosis;

    Sammanfattning : Thrombin-derived C-terminal peptides (TCPs) constitute a novel class of immunomodulatory host defense peptides, generated during infection and inflammation. Previous investigations have shown that TCPs of 2-3 kDa inhibit pro-inflammatory immune responses in vitro and in vivo, but their mode of action remained unclear. LÄS MER