Sökning: "THE NEW SYNTHESIS"

Visar resultat 1 - 5 av 1218 avhandlingar innehållade orden THE NEW SYNTHESIS.

1. 1. NEW OLIGOTHIOPHENES

   Författare :Fredrik von Kieseritzky; KTH; []
   Nyckelord :oligothiophenes; synthesis; light-emitting diodes; field-effect transistors; photoluminescence; quantum efficiency;

   Sammanfattning : This thesis deals with synthesis and characterization of newoligothiophenes and derivatives thereof, for use as organicsemiconductors in optical and electronic applications, such asfield-effect transistors and light-emitting diodes. Much workis devoted to the development of new synthetic strategies forinteresting building blocks, to beused for synthesizing suchmaterials. LÄS MER

3. 2. New synthetic routes to azaspiro alkaloids : Applications to the synthesis perhydrohistrionicotoxin

   Författare :Lars Hagberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : Perhydrohistrionicotoxin, 1, is related to a family of alkaloids which display pharmacologically interesting properties. The thesis deals with development of new methods for the chemical synthesis of such alkaloids, and is divided into three parts according to the different approaches. LÄS MER

4. 3. The Protein Traffic on the Ribosome : The Mechanism and Regulation of Protein Synthesis in Prokaryotes

   Författare :Andrey Zavialov; Måns Ehrenber; Venki Ramakrishnan; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; yellow; ribosome; translation; Gagarin; nobel prize; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : The aim of this work was to understand the molecular mechanism of translation and the mechanism of translation termination, in particular. Cleavage of peptidyl-tRNA and peptide release terminates translation of mRNA on the ribosome. In prokaryotes, three release factors (RFs) are involved in this process. LÄS MER

5. 4. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis

   Författare :Malin Graffner Nordberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; soft drug; dihydrofolate reductase; synthesis; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

   Sammanfattning : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). LÄS MER

7. 5. The /k/s, the /t/s, and the inbetweens : Novel approaches to examining the perceptual consequences of misarticulated speech

   Författare :Sofia Strömbergsson; David House; Åsa Wengelin; Benjamin Munson; KTH; []
   Nyckelord :HUMANIORA; HUMANITIES; speech perception; speech disorders; speech synthesis; speech analysis; Tal- och musikkommunikation; Speech and Music Communication;

   Sammanfattning : This thesis comprises investigations of the perceptual consequences of children’s misarticulated speech – as perceived by clinicians, by everyday listeners, and by the children themselves. By inviting methods from other areas to the study of speech disorders, this work demonstrates some successful cases of cross-fertilization. LÄS MER