Sökning: "soft drug"
Visar resultat 1 - 5 av 44 avhandlingar innehållade orden soft drug.
1. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis
Sammanfattning : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). LÄS MER
2. Advancing portable, aqueous drug delivery to the human lung
Sammanfattning : Lung disease profoundly impacts human health: many lung diseases are currently without cure and require continued treatment. Due to their ease of use and integration into the daily routine, portable inhalers are the preferred treatment option for patients. LÄS MER
3. Quantitative 3D reconstruction of porous polymers using FIB-SEM tomography -correlating materials structures to properties of coatings for controlled drug release
Sammanfattning : Porous networks are found in a wide range of different advanced and technologically important materials and influence the materials properties. The networks are active components in for example batteries, food and pharmaceuticals. The interconnectivity of a network strongly influences the transport properties. LÄS MER
4. Hydrogels of Poly(vinyl alcohol) and Nanocellulose for Ophthalmic Applications : Synthesis, Characterization, Biocompatibility and Drug Delivery Studies
Sammanfattning : Hydrogels are commonly used materials in ophthalmic care as contact lenses, bandage lenses, corneal implants, and cornea regeneration scaffolds. Hydrogels can be produced by physical, chemical, or radiation crosslinking of hydrophilic polymers. LÄS MER
5. Preparation of Tablets from Reservoir Pellets with an Emphasis on the Compression Behaviour and Drug Release
Sammanfattning : The preparation of multiple unit tablets was investigated in this thesis with the intention of gaining a deeper understanding of some of the factors that influence the properties of such tablets.Initially, three different types of pellets (drug, soft and disintegrant pellets) were combined as a model to investigate the ability of the mixture to form disintegrating tablets. LÄS MER