Sökning: "TCR usage"

Visar resultat 11 - 15 av 22 avhandlingar innehållade orden TCR usage.

  1. 11. CD8+ T cell specificity in thymic selection and in the recognition of antigen

    Författare :Johan Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T cell; specificity; MHC class 1; selection; tolerance;

    Sammanfattning : Specificity mediated by the T cell receptor (TCR) is of fundamental importance for the ability of T cells to function, and regulate humoral immunity and effector mechanisms of the innate immune system. T cells recognize composite molecules consisting of products of the major histocompatibility complex (MHC) class I or class 11 loci, in complex with a short peptide fragment derived from endogenous or antigenic proteins. LÄS MER

  3. 12. Interstitial lung disease in polymyositis and dermatomyositis

    Författare :Maryam Fathi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :dermatomyositis; polymyositis; interstitial lung disease;

    Sammanfattning : Polymyositis and dermatomyositis are rare disease entities affecting skeletal muscle and other organs such as the lungs. Interstitial lung disease (ILD) is increasingly recognized as a serious complication of poly-/dermatomyositis. LÄS MER

  4. 13. Studies of the immunopathogenesis in three arthritis models in rats

    Författare :Helena Erlandsson Harris; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :experimental arthritis; inflammation; adjuvants; T-cell receptor; collagen type II; cartilage oligomeric matrix protein COMP ;

    Sammanfattning : The immunopathogenesis of three arthritis models has been studied; oil-induced arthritis (OIA), homologous collagen-induced arthritis (CIA) and COMP-induced arthritis. The induction of a monophasic arthritis, OIA, in the DA rat with a single intradermal injection of Freund's incomplete adjuvant (FIA) was reported. LÄS MER

  5. 14. Human intraepithelial lymphocytes : a comparative study of phenotype, morphology, and functional properties of intraepithelial lymphocytes in gut and oral mucosa

    Författare :Carina Lundqvist; Marie-Louise Hammarström; Sten Hammarström; Per Brandtzaeg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intraepithelial lymphocytes; alimentary tract; intestinal epithelium; gut luminal antigens; gingiva; γδ T cells; immunoelectron microscopy; cytokine mRNA; RT-PCR; extrathymic T cell maturation; RAG-1; periodontitis; mucosal immune system; CD4-CD8- αβ T cells; CD8 γδ T cells;

    Sammanfattning : Human intraepithelial lymphocytes (IEL) constitute a unique cell population situated in the first line of defense of the alimentary tract. Here they are continuously exposed to a massive antigenic load of high complexity. However, different conditions prevail along the alimentary tract. LÄS MER

  7. 15. Molecular mechanisms of antibody diversification in human B-cells

    Författare :Andrea Björkman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : B-cells undergo several somatic rearrangement/mutational processes during development to diversify their immunoglobulin (Ig) receptors. First, the antigen binding Ig variable (V) region is assembled through V(D)J recombination. LÄS MER