Sökning: "TCR usage"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden TCR usage.

1. 6. Inflammatory mechansims in pulmonary sarcoidosis

   Författare :Mary Berlin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adhesion molecules; alveolitis; bronchoalveolar lavage; bronchial hyperreactivity; extracellular matrix molecules; extrinsic allergic alveolitis; fibrosis; HLA-DR; sarcoidosis; TCR;

   Sammanfattning : Pulmonary sarcoidosis is an inflammatory disorder of unknown aetiology, characterised by an accumulation of CD4+ T-cells in the alveolar compartment and by granuloma formation and varying degrees of interstitial fibrosis. The initial clinical presentation may either be acute with fever, malaise, arthritis and/or erythema nodosum or insidious with cough, dyspnea, tiredness, and loss of weight. LÄS MER

3. 7. Some studies on human aB+ and yd+ T lymphocytes in health and disease

   Författare :Semih Esin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T cell receptor; Autoimmunity; Mycobacteria; Behcet s disease; Flow cytometry; Proliferation; Intestine; yd T cells; Infection;

   Sammanfattning : T lymphocytes use the T cell receptor (TCR) to specifically recognize antigens. According to the type of TCR heterodimer, T cells can be phenotypically divided into a B+ or yd+ subsets. In many human inflammatory/autoimmune diseases significant expansions of aB+ and yd+ T cells have been described. LÄS MER

4. 8. Molecular mechanisms of HLA associations with myasthenia gravis

   Författare :Peter Hjelmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myasthenia gravis; MHC; HLA; T cell receptor; acetylcholine receptor; TNF-a; thymus complex disease trait; autoimmunity; molecular modelling; stratification; DNA polymorphisms;

   Sammanfattning : Myasthenia gravis (MG) is a neuromuscular disease characterised by muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR). MG has a complex pattern of inheritance and several genetic and environmental factors are important in conferring susceptibility to the disease. LÄS MER

5. 9. Control of Epstein-Barr virus infection by cytotoxic T lymphocytes

   Författare :Pedro-Otavio de Campos-Lima; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Epstein-Barr virus; Cytotoxic T lymphocytes; T cell receptor; CTLescape mutants;

   Sammanfattning : Cytotoxic T lymphocytes (CTL) play a critical role in response to Epstein-Barr virus (EBV), a widespread human herpes virus that persists in healthy carriers as a latent infection of B cells and is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. Six virus encoded nuclear antigens, EBNA1-6, and three membrane proteins, LMP1, -2A and -2B, are regularly detected in EBV transformed lymphoblastoid cell lines (LCLs). LÄS MER

7. 10. Studies of immune mechanisms in myasthenia gravis

   Författare :Biying Xu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :myasthenia gravis; acetylcholine receptor; ß-adrenergic receptor; antibody; T cell receptor; antibody-dependent cell-mediated cytotoxicity; gene polymorphism;

   Sammanfattning : Myasthenia gravis (MG) has been considered the prototype of autoantibody-mediated autoimmune diseases. The pathogenic autoantibodies are directed against the acetylcholine receptor (AChR). Several mechanisms by which these antibodies (AChR Ab) disturb the function of the receptor have been elucidated. LÄS MER