Sökning: "Statins"

Visar resultat 26 - 30 av 92 avhandlingar innehållade ordet Statins.

1. 26. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

   Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

   Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

3. 27. Modulation of bile acid and cholesterol metabolism in health and disease

   Författare :Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

   Sammanfattning : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. LÄS MER

4. 28. Statin-induced cellular effects mediated by the P2X7 receptor

   Författare :Oras Mistafa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cholesterol-lowering statins have been shown to inhibit growth of different cancer cells both in vitro and in vivo. Epidemiological studies also indicate a chemopreventive effect of statins. We have investigated the effect of statins on Akt/protein kinase B signaling and their sensitizing effect of cytostatic drugs. LÄS MER

5. 29. Pleiotropic effects of HMG-CoA reductase inhibitors : studies in vitro and in vivo

   Författare :Cristine Skogastierna; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cardiovascular disease (CVD) is the prime cause of death in industrialized countries, resulting from the progression of atherosclerotic lesions. An increased level of plasma cholesterol, particularly within low-density lipoproteins, is a principle risk factor, but also elevated triglycerides and low levels of high-density lipoprotein cholesterol. LÄS MER

7. 30. Use of secondary preventive drugs after stroke

   Författare :Maria Sjölander; Eva-Lotta Glader; Rune Dahlqvist; Marie Eriksson; Björn Wettermark; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; secondary prevention; drug use; equality; medication adherence; medication beliefs; medicin; Medicine; klinisk farmakologi; Clinical Pharmacology; samhällsfarmaci; Social Pharmacy;

   Sammanfattning : Background Stroke is a serious condition that can have significant impact on an individual’s health and is a significant burden on public health and public finances. Secondary preventive drug treatment after stroke is important for decreasing the risk of recurrent strokes. LÄS MER