Sökning: "myeloperoxidase"

Visar resultat 1 - 5 av 55 avhandlingar innehållade ordet myeloperoxidase.

  1. 1. Therapeutic opportunities of alpha-1-microglobulin A study in placenta, blood, skin and eye

    Författare :Martin Cederlund; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reactive oxygen species; hemoglobin; myeloperoxidase; oxidative stress; α1-microglobulin;

    Sammanfattning : This thesis describes functional studies of the human protein alpha-1-microglobulin (A1M), with the aim of exploring its usefulness as a therapeutic agent in diseases where oxidative stress is a prominent feature. A1M is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding antioxidative functions. LÄS MER

  2. 2. Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands

    Författare :Hülya Çevik Aras; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :salivary glands; protein secretion; synthesis; inflammation; β-defensins; myeloperoxidase; cholecystokinin; gastrin; melatonin; nitric oxide; nerve stimulation;

    Sammanfattning : Textbooks generally state that the secretory activity of salivary glands is solely regulated by nerves. This view is challenged in the present Thesis, using the parotid gland of the anaesthetized rat as experimental in vivo model. LÄS MER

  3. 3. Gut Mucosal Reactivity to Gluten and Cow´s Milk Protein in Rheumatic Diseases

    Författare :Maria Lidén; Roger Hällgren; Gudjón Kristjánsson; Sigrídur Valtýsdóttir; Thomas Skogh; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Primary Sjögren’s syndrome; rheumatoid arthritis; spondyloarthropathies; rectal challenge; food sensitivity; myeloperoxidase; nitric oxide and barrier permeability; Rheumatology; Reumatologi; Medicine; medicin;

    Sammanfattning : This thesis comprised patients with chronic rheumatic diseases. The studies aimed to elucidate food sensitivity by measuring mucosal inflammatory reactivity and thereby a possible link between the gut and joints. LÄS MER

  4. 4. High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation

    Författare :Xiaojiao Sun; Lars Baltzer; Thomas Norberg; Ulf Nilsson; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; polypeptide; conjugates; D-dimer; myeloperoxidase; chitinase;

    Sammanfattning : This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. LÄS MER

  5. 5. Autoimmunity in glomerulonephritis; serological diagnosis and clinical outcome with special reference to Wegener´s granulomatosis and microscopic polyangiitis

    Författare :Kerstin Westman; Njurmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wegener´s granulomatosis; vasculitis; thyroid peroxidase antibodies; proteinase 3; myeloperoxidase; antineutrophil cytoplasmic antibodies; ANCA; thyroiditis; autoantibodies; glomerulonephritis; microscopic polyangiitis; Urology; nephrology; Urologi; nefrologi;

    Sammanfattning : Autoantibodies of different specificites have been described in association with glomerulonephritis and therefore the aim of this thesis was to improve our knowledge of the different manifestations of autoimmune phenomena which are involved in the glomerulonephritides. Special reference is made to Wegener´s granulomatosis (WG) and microscopic polyangiitis (MP) which are frequently associated with the prevalence of anti-neutrophil cytoplasmic antibodies (ANCA). LÄS MER