Sökning: "ischaemiareperfusion injury"

Hittade 3 avhandlingar innehållade orden ischaemiareperfusion injury.

  1. 1. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

  3. 2. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Författare :Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Sammanfattning : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. LÄS MER

  4. 3. Inorganic and organic nitrates as sources of nitric oxide

    Författare :Mirco Govoni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inorganic nitrate (NO3-) and nitrite (NO2-) have generally been considered stable inactive end products of nitric oxide (NO) or unwanted residues in the food chain. While several recent studies surprisingly demonstrate that nitrite is reduced to bioactive NO in blood and tissues, the more stable anion nitrate is still considered to be inert. LÄS MER