Sökning: "Smad3"

Visar resultat 6 - 10 av 24 avhandlingar innehållade ordet Smad3.

1. 6. Ligand-receptor interactions and signaling cross-talk in the TGF-b superfamily

   Författare :Andries Blokzijl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The transforming growth factor-beta (TGF-beta) superfamily of secreted polypeptide growth factors forms part of an evolutionary conserved signaling pathway, present in diverse organisms from flies to humans, used in intercellular communication. The TGF-beta family comprises more than 40 members in vertebrates, Caenorhabditis elegans and Drosophila melanogaster. LÄS MER

3. 7. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

   Författare :Maria Simonsson; Johan Ericsson; Eva Grönroos; Marikki Laiho; Uppsala universitet; []
   Nyckelord :Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

   Sammanfattning : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. LÄS MER

4. 8. Regulation of TGF-β Signaling by Post-Translational Modifications

   Författare :Peter Lönn; Aristidis Moustakas; Carl-Henrik Heldin; Petra Knaus; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. LÄS MER

5. 9. Gene regulation by different proteins of TGFβ superfamily

   Författare :Varun Maturi; Aristidis Moustakas; Anita Göndör; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EMT; Snail1; ZEB1; TGFβ; BMP; Gene regulation;

   Sammanfattning : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. LÄS MER

7. 10. Smad7 in TGF-β Signalling

   Författare :Greger Brodin; Stefan Karlsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; TGF-β; Smad7; Prostate; Transcription; Gene targeting; Onkologi; Oncology; Onkologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Members of the transforming growth factor-β (TGF-β) superfamily of growth and differentiation factors regulate a vast array of biological functions in the adult, and are of great importance in governing cell fate determination and patterning in the developing embryo. The TGF-β signal is propagated intracellularly by Smad proteins resulting in transcriptional responses. LÄS MER