Sökning: "Smad3"

Visar resultat 16 - 20 av 24 avhandlingar innehållade ordet Smad3.

  1. 16. The role of angiopoietin-like 4 in inflammation

    Författare :Terri Phua; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation is a homeostatically fundamental feature of the host defence surveillance system made up of an army of sentinel cells that guard against foreign intrusion. At the onslaught of an attack, primary immune responders (macrophages and neutrophils) secrete a plethora of cytokines and chemokines that attract secondary responders (T and B cells) to the site of inflammation, to eliminate the intrusion and encourage tissue healing. LÄS MER

  3. 17. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

    Författare :Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. LÄS MER

  4. 18. Oral lichen planus : studies of factors involved in differentiation, epithelial mesenchymal transition and inflammation

    Författare :Karin Danielsson; Karin Nylander; Ylva Britt Wahlin; Linda Boldrup; Jesper Reibel; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oral lichen planus; differentiation; inflammation; autoimmune; premalign; odontologi; Odontology; patologi; Pathology;

    Sammanfattning : Background: Lichen planus is a chronic inflammation of skin and mucosa with unknown cause. Oral Lichen Planus, OLP, affects around 2% of the population. Autoimmunity has been suggested as a possible cause as the disease has autoimmune features such as female predominance, cyclic nature and cytotoxic T-cell infiltrate. LÄS MER

  5. 19. TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics

    Författare :Nimesh Bhaskaran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transforming growth factor-beta (TGFbeta) is a key regulator of cell proliferation, death, migration and differentiation. One of the features of TGFbeta signaling is to inhibit tumor growth at the early stage of cancer but promotes tumorigenesis at the advanced stage. LÄS MER

  7. 20. Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways

    Författare :Tomas Jakobsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat metabolism. Recently, the LXRs have emerged as important regulators of the innate and adaptive immune system and inflammation. LÄS MER