Sökning: "Smad3"

Visar resultat 11 - 15 av 24 avhandlingar innehållade ordet Smad3.

  1. 11. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice

    Författare :Fei Tian; Göteborgs universitet; []
    Nyckelord :hypoxia; angiogenesis; mice; endoglin; SUMO; PDI;

    Sammanfattning : Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. LÄS MER

  3. 12. The life and death of the notch intracellular domain

    Författare :Camilla Öberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling pathway is an evolutionarily conserved way of communicating between cells that contact each other. Notch is a single-transmembrane spanning receptor that interacts with single-transmembrane spanning ligands on adjacent cells. In vertebrates the Notch family of receptor consists of four members: Notch1 to Notch4. LÄS MER

  4. 13. Molecular and epigenetic control of CNS tumour and progenitor cells

    Författare :Aileen Gracias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite advances in diagnosis and treatment, CNS tumours continue to result in high mortality and morbidity. Glioblastoma mutliforme (GBM), the most common primary brain tumour, is a recurrent tumour that despite advances in treatment, continues to demonstrate a median time of survival of 14.6 months. LÄS MER

  5. 14. Regulation of TGF-β/Smad Signaling Through Smad Interacting Proteins

    Författare :Fumiko Itoh; Carl-Henrik Heldin; Peter ten Dijke; Carlos F. Ibáñez; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Transforming growth factor-β (TGF-β) superfamily members are multi-functional regulators of cell fate. These factors signal by binding to a limited number of highly conserved transmembrane type I and type II serine/threonine kinase receptors. These receptors initiate signals into the cell via the Smad proteins. LÄS MER

  7. 15. Corneal stromal cell responses to traumatic wounds and topical treatments

    Författare :Marina Kulikovska; Per Fagerholm; Neil Lagali; Anders Behndig; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Background. The cornea has unique anatomic, cellular, molecular, and functional features that lead to important mechanistic differences in the process of repair in comparison with what occurs in skin and other organs. The first observable stromal response in corneal wound healing is keratocyte apoptosis. LÄS MER