Sökning: "Ras MAP kinase pathway"
Hittade 5 avhandlingar innehållade orden Ras MAP kinase pathway.
1. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2
Sammanfattning : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. LÄS MER
2. Cell fate specification by Ras-mediated cell signalling in C. elegans
Sammanfattning : Induction of vulval fates in the C. elegans hermaphrodite is mediated by a conserved RTK/Ras/MAP kinase signalling pathway, in which the core components can be placed into a linear genetic and biochemical pathway. However, the events that occur downstream of this pathway are not yet well understood. LÄS MER
3. Role of the map kinase pathways in maintenance of the transformed phenotype
Sammanfattning : In order to interfere pharmacologically with tumor growth and metastasis, it is of great importance to understand the status of the signal transduction systems in tumor cells. The effect of various oncogenes on cellular signal transduction events has largely been studied in short term experiments. LÄS MER
4. Structural and Functional Aspects of β1 Integrin Signalling
Sammanfattning : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. LÄS MER
5. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers
Sammanfattning : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. LÄS MER
