Sökning: "Sofia Edin"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Sofia Edin.

  1. 1. Calmodulin mediated regulation of NF-kappaB in lymphocytes

    Författare :Sofia Edin; Thomas Grundström; Sam Okret; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium; CaM; CaMKII; NF-kappaB; Bc110; immunological synapse; Molecular biology; Molekylärbiologi;

    Sammanfattning : NF-κB transcription factors are regulators of a wide spectrum of genes involved in immune responses and inflammation as well as cellular proliferation and survival. Transcriptionally competent NF-κB dimers are retained in the cytoplasm of resting cells by binding to inhibitors of NF-κB (IκBs). LÄS MER

  3. 2. Automation and the Consequences of Occupational Decline

    Författare :Sofia Hernnäs; Georg Graetz; Per-Anders Edin; Sebastian Findeisen; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; technological change; automation; routine-biased technological change; skill prices; skill bundling; occupations; inequality; health; death of despair; Economics; Nationalekonomi;

    Sammanfattning : Essay I. Automation affects workers because it affects the return to their skills when performing different tasks. I propose a general equilibrium model of occupational choice and technological change which takes two important labor market features into account: (i) automation happens to tasks and (ii) workers have bundled skills. LÄS MER

  4. 3. Two facets of Innovation in Engineering Education : The interplay of Student Learning and Curricula Design

    Författare :Anders Berglund; Sofia Ritzén; Martin Edin Grimheden; Margareta Norell Bergendahl; William Ion; KTH; []
    Nyckelord :Engineering education; innovation; design; learning elements; student; change; Ingenjörsutbildning; innovation; design; lärandeelement; student; förändring;

    Sammanfattning : This thesis covers two main perspectives ofinnovation; first, innovation is regarded as an outcome-related mechanism wherelearning is expressed through artefact presentations at the end of adevelopment process; second, innovation comprises a change mechanism in theprocess of student learning, influencing educators to reconsider new methods andpractices. Building on qualitative data from engineering design courses, theaim has been to explore how learning elements in engineering educationinfluence students during early-phase innovation. LÄS MER

  5. 4. Immune cell infiltration and prognosis in colorectal cancer

    Författare :Agnes Ling; Richard Palmqvist; Sofia Edin; Xingru Li; Ola Winqvist; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Colorectal cancer; molecular subgroups; immune cell infiltration; immune escape; prognosis;

    Sammanfattning : Background: Colorectal cancer (CRC) is globally the second most common form of cancer among women, and third in men. It is also one of the most common causes of cancer-related death in high-income countries. Surgical resection is the basis for curative therapy but still almost half of the patients die from metastatic disease. LÄS MER

  7. 5. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

    Författare :Ida Lundberg; Richard Palmqvist; Maria Wikberg; Sofia Edin; Anita Sjölander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; BRAF; KRAS; SOX2; CDX2; cancer stem cell; Th1 lymphocytes; miRNA; prognosis;

    Sammanfattning : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. LÄS MER