Sökning: "QTL"

Visar resultat 16 - 20 av 98 avhandlingar innehållade ordet QTL.

1. 16. Genetic and genomic analysis of arthritis regulating regions in human and mouse

   Författare :Lina Olsson; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Immunologi; serologi; transplantation; Skeleton; muscle system; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; QTL; NADPH oxidase complex; Rheumatoid Arthritis; Genetic Analysis;

   Sammanfattning : Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. LÄS MER

3. 17. Numerical methods for mapping of multiple QTL

   Författare :Kajsa Ljungberg; Sverker Holmgren; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Beräkningsvetenskap; Scientific Computing;

   Sammanfattning : This thesis concerns numerical methods for mapping of multiple quantitative trait loci, QTL. Interactions between multiple genetic loci influencing important traits, such as growth rate in farm animals and predisposition to cancer in humans, make it necessary to search for several QTL simultaneously. LÄS MER

4. 18. Two Optimization Problems in Genetics : Multi-dimensional QTL Analysis and Haplotype Inference

   Författare :Carl Nettelblad; Sverker Holmgren; José M. Álvarez-Castro; Jukka Corander; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; quantitative trait loci; genome-wide association studies; hidden Markov models; numerical optimization; linkage analysis; haplotype inference; genotype imputation; high performance computing;

   Sammanfattning : The existence of new technologies, implemented in efficient platforms and workflows has made massive genotyping available to all fields of biology and medicine. Genetic analyses are no longer dominated by experimental work in laboratories, but rather the interpretation of the resulting data. LÄS MER

5. 19. Correlated selection responses in animal domestication : the behavioural effects of a growth QTL in chickens

   Författare :Anders Wirén; Per Jensen; Elena Jazin; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Studying animal domestication offers an opportunity to understand the mechanisms of evolution. Domestication is associated with a change in selection pressures; selection for production traits is introduced, and animals are faced with larger and denser social groups. LÄS MER

7. 20. An e-Science Approach to Genetic Analysis of Quantitative Traits

   Författare :Mahen Jayawardena; Sverker Holmgren; Erwin Laure; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QTL Analysis; Grid Computing; Global Optimization; e-Science; Beräkningsvetenskap; Scientific Computing;

   Sammanfattning : Many important traits in plants, animals and humans are quantitative, and most such traits are generally believed to be affected by multiple genetic loci. Standard computational tools for mapping of quantitative traits (i.e. LÄS MER