Sökning: "QTL"

Visar resultat 21 - 25 av 98 avhandlingar innehållade ordet QTL.

  1. 21. Selection during Early Life Stages and Local Adaptation in Arabidopsis thaliana

    Författare :Froukje M. Postma; Jon Ågren; Kathleen Donohue; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dormancy cycling; Germination timing; Maternal effects; Natural variation; QTL mapping; Seed bank; Seed dormancy; Structural Equation Modeling; Biology with specialization in Ecological Botany; Biologi med inriktning mot ekologisk botanik;

    Sammanfattning : Organisms are often adapted to their local environment, but the role of early life stages in adaptive differentiation among populations remains poorly known. The aim of my thesis was to investigate the contribution of early life stages to the magnitude and genetic basis of local adaptation, and to identify the underlying adaptive traits. LÄS MER

  3. 22. Novel strategies to explore The complex genetics of autoimmune diseases

    Författare :Martina Johannesson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunology; serology; Immunologi; serologi; cytogenetik; Genetik; cytogenetics; Genetics; collagen induced arthritis; QTL mapping; complex traits; autoimmunity; genetics;

    Sammanfattning : Autoimmune diseases are dependent on both genetic and environmental factors in complex interplay. They arise from a faulty immune response against self-antigens, and causes great suffering in affected individuals. Despite large efforts and hundreds of thousands of research articles published, the disease etiologies remain largely unknown. LÄS MER

  4. 23. Methods from Statistical Computing for Genetic Analysis of Complex Traits

    Författare :Behrang Mahjani; Sverker Holmgren; Lars Rönnegård; Carl Nettelblad; Silvia Delgado Olabarriaga; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Statistical Computing; QTL mapping; Global Optimization; Linear Mixed Models; Scientific Computing; Beräkningsvetenskap;

    Sammanfattning : The goal of this thesis is to explore, improve and implement some advanced modern computational methods in statistics, focusing on applications in genetics. The thesis has three major directions.First, we study likelihoods for genetics analysis of experimental populations. LÄS MER

  5. 24. Numerical Algorithms for Optimization Problems in Genetical Analysis

    Författare :Kateryna Mishchenko; Sverker Holmgren; Dmitrii Silvestrov; Lars Rönnegård; Ann-Charlotte Berglund Sonnhammer; Mälardalens högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quantitative Trait Loci QTL ; restricted maximum likelihood REML ; variance components; average information AI matrix; Local optimization; Quasi-Newton method; Active Set method; Hessian approximation; BFGS update; Applied mathematics; Tillämpad matematik; Matematik tillämpad matematik;

    Sammanfattning : The focus of this thesis is on numerical algorithms for efficient solution of QTL analysis problem in genetics.Firstly, we consider QTL mapping problems where a standard least-squares model is used for computing the model fit. LÄS MER

  7. 25. Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis

    Författare :Hai-Tao Yang; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Collagen induced arthritis CIA ; Experimental allergic encephalomyelities EAE ; Multiple sclerosis MS ; Quantitative trait loci QTL ; Rheumatoid arthritis RA ; Linkage analysis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. LÄS MER