Sökning: "Peripheral aberrations"

Visar resultat 26 - 30 av 32 avhandlingar innehållade orden Peripheral aberrations.

1. 26. Variability of blood pressure and heart rate in borderline and mild hypertension : With special reference to spectral analysis

   Författare :Reijo Takalo; Uppsala universitet; []
   Nyckelord :Medical sciences; hypertension; blood pressure; ambulatory monitoring; power spectrum analysis; pulsecontour method; systemic hemodynamics; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Physiology; klinisk fysiologi;

   Sammanfattning : The aim of this thesis was to study whether blood pressure (BP) or heart rate (HR) variability in borderline (BHT) and hypertensive (HT) subjects differs from that in normotensive (NT) subjects, and whether indices for BP and HR variability can be used in risk stratification for future hypertension. The study groups consisted of 35 NT, 29 BHT, and 34 HT middle-aged men. LÄS MER

3. 27. Clinical prognostic markers in chronic lymphocytic leukemia

   Författare :Stefan Norin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. The clinical course for the individual patient is still unpredictable despite decades of research on prognostic markers and staging systems. LÄS MER

4. 28. Molecular Genetic and DNA Methylation Profiling of Chronic Lymphocytic Leukaemia : A Focus on Divergent Prognostic Subgroups and Subsets

   Författare :Nicola Cahill; Richard Rosenquist; Larry Mansouri; Fergus Ryan; Denis Alexander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; Chronic lymphocytic leukemia; SNP; array; IGHV3-21; IGHV4-34; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Genetics; Genetik; Medical Genetics; Medicinsk genetik; Molecular Biology; Molekylärbiologi; Molekylär genetik; Molecular Genetics; Oncology; Onkologi;

   Sammanfattning : Advancements in prognostication have improved the subdivision of chronic lymphocytic leukaemia (CLL) into diverse prognostic subgroups. In CLL, IGHV unmutated and IGHV3-21 genes are associated with a poor-prognosis, conversely, IGHV mutated genes with a favourable outcome. LÄS MER

5. 29. Insulin and IGF-I in type 1 diabetes

   Författare :Christina Hedman; Claes-Göran Östenson; Linköpings universitet; []
   Nyckelord :Type I diabetes; IGF-I; IGF system; insulin; insulin analogues; MEDICINE; MEDICIN;

   Sammanfattning : Patients with type I diabetes have alterations in the GH/IGF system with reduced levels of circulating IGF-I, as well as other disturbances in the components of the IGF system.Alterations of both local and circulating IGF-I and its binding proteins (IGFBPs) have been associated with metabolic and vascular manifestations of diabetes and also with atherosclerosis. LÄS MER

7. 30. Interphase cytogenetics and cytokine therapy in myelodysplastic syndromes and acute myeloid leukemia

   Författare :Per Bernell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :myelodysplastic syndromes; acute myeloid leukemia; FISH; clonality; lineageinvolvement; minimal residual disease; EIPO; GM-CSF.;

   Sammanfattning : Myelodysplastic syndromes (MDS) comprise a group of clonal hematopoietic bone marrow cell disorders, characterized by a variable degree of anemia, granulocytopenia and/or thrombocytopenia and with a substantial risk of transformation to acute myeloid leukemia (MDS-AML). In the present thesis a method based on fluorescence in situ hybridization (FISH) was developed which allows cytogenetic studies on morphological identified peripheral blood and bone marrow cells (MGG/FISH). LÄS MER