Sökning: "clonality"

Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet clonality.

  1. 1. Molecular Pathogenesis of Cervical Carcinoma : Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

    Författare :Xinrong Hu; Björn Hagmar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. LÄS MER

  3. 2. Molecular mechanisms in cervical carcinogenesis : Studies of clonality, somatic genetic alterations and human papillomavirus variants in cervical pre-invasive and invasive cancer

    Författare :Zhongmin Guo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical cancer; CIN; clonality; X-chromosome inactivation; LOH; HPV; chromosome 3p; chromosome 6; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Cervical cancer derives from a series of pre-invasive cervical neoplastic lesions termed CIN I-III (Cervical Intraepithelial Neoplasia) via typical multiple-step processes. In contrast to premalignant disorders in other organs, different degrees of CIN possess a distinct biological behaviour where a proportion spontaneously regress or persist, whereas some progress to invasive cancer. LÄS MER

  4. 3. On the endemic Fucus radicans in the Baltic Sea

    Författare :Ellen Schagerström; Lena Kautsky; Inga Kjersti Sjøtun; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; seaweed; sexual reproduction; clonality; fragmentation; dimorphism; salinity; distribution; Plant Ecology; växtekologi;

    Sammanfattning : The brown macroalgae Fucus radicans is endemic to the Baltic Sea, but little is known about this newly described species. This thesis investigates the ecology and role of F. radicans within the species poor Baltic Sea ecosystem. The thallus of F. LÄS MER

  5. 4. Evolution in multicellular mitotic lineages

    Författare :Mario Pineda; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mosaic; modular organisms; spatial interactions; individualtiy; somatic embryogensis; ontogeny; clonality; meristem; chimera; Ecology; Ekologi;

    Sammanfattning : Many animals, and all plants and fungi, produce vegetative offspring, i.e. descendant individuals that originate from mitotic, rather than meiotic, cell lineages. Many animals, and all plants and fungi, produce vegetative offspring, i. LÄS MER

  7. 5. Molecular progression and clonality or urinary bladder cancer

    Författare :Jari Louhelainen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The general aim of this work was to investigate the clonality of multifocal bladder tumours, chromosomal deletions and model the initiation-progression of bladder tumours at a molecular level using microsatellite analysis. In a population-based study, we found correlation between stage and grade and the prevalence of loss of heterozygosity (LOH) at all observed chromosome 13 loci and stage and grade, respectively. LÄS MER