Sökning: "Parkinsonism"

Visar resultat 16 - 20 av 46 avhandlingar innehållade ordet Parkinsonism.

  1. 16. Magnetic resonance imaging techniques for diagnostics in Parkinson's disease and atypical parkinsonism

    Författare :Henrik Sjöström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history and treatment response. LÄS MER

  3. 17. L-DOPA-induced signaling pathways and neuroepigenetic mechanisms in experimental parkinsonism and dyskinesia

    Författare :Michael Feyder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In patients with Parkinson’s disease (PD), the restoration of depleted striatal dopamine by chronic administration of its precursor, L-DOPA, results in the emergence of debilitating involuntary movements. This complication, termed L-DOPA-induced dyskinesia (LID), represents a limitation to the most efficacious treatment for PD motor symptoms. LÄS MER

  4. 18. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease

    Författare :Katrine Skovgård; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease Parkinsonism; Dyskinesia; Drug-Induced; Oscillations; Local field potentials; Impulsive-compulsive behaviours; Dopamine agonists; Animal Models; Pharmacology;

    Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. LÄS MER

  5. 19. The Biophysics of Na+,K+-ATPase in neuronal health and disease

    Författare :Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

    Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER

  7. 20. Early trauma/dysmorphogenesis and adult neurodysfunction in schizophrenia

    Författare :Baher Ismail; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychiatry; clinical psychology; klinisk psykologi; neurodevelopmental model; psychosomatics; Psykiatri; tardive dyskinesia; neurological abnormality; neurocognitive dysfunction; dermatoglyphics; head circumference; minor physical anomalies; Schizophrenia; obstetric complications; psykosomatik;

    Sammanfattning : To measure the importance of early neurodevelopmental disturbance for schizophrenia, early trauma and dysmorphogenesis (i.e. obstetric complications (OCs), minor physical anomalies (MPAs), head circumference (HC) and dermatoglyphic characteristics) were studied in relationship to adult neurodysfunction (i.e. LÄS MER