Sökning: "Pancreatic ductal adenocarcinoma"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden Pancreatic ductal adenocarcinoma.

1. 1. Prognostic role of the tumour microenvironment in esophago-gastric, pancreatic and periampullary adenocarcinoma: B cells and beyond

   Författare :Richard Fristedt; Tumörmikromiljö; []
   Nyckelord :Polymeric immunoglobulin receptor; B cells; Plasma cells; Esophageal adenocarcinoma; gastric adenocarcinoma; Pancreatic ductal adenocarcinoma; Periampullary adenocarcinoma; Prognosis and survival; Immune system;

   Sammanfattning : Cancer development depends on cells aquiring a skillset of limitless growth and finally invasive properties to allow for metastasis, as summarised by the six hallmarks of cancer. Recently four more hallmarks have been added: genomic instability, deregulating cellular metabolism, tumour-promoting inflammation and avoiding immune destruction. LÄS MER

3. 2. Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro

   Författare :Heléne Lindholm; Katarina Ejeskär; Ferenc Szekeres; Maria Faresjö; Sofie Mohlin; Högskolan i Skövde; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic ductal adenocarcinoma; Na K -ATPase; digitoxin; cardiac glycoside; metabolomics; choline; Translationell medicin TRIM; Translational Medicine TRIM;

   Sammanfattning : The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens. Since the development of new cancer treatments are expensive and time consuming, repurposing drugs is preferable when possible. LÄS MER

4. 3. Advances in the Perioperative Management of Pancreatic Cancer

   Författare :Srinivas Sanjeevi; Christoph Ansorge; Sara Regnér; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; pancreatic ductal adenocarcinoma; prophylactic double bypass; pancreaticojejunostomy; neoadjuvant chemotherapy; post-operative pancreatic fistula; Kirurgi; Surgery;

   Sammanfattning : Surgery is currently the only form of curative treatment for pancreatic cancer, yet five-year survival rates following resection are just 15-20%. Improved hospital care has decreased postoperative mortality to 2% yet morbidity remains high at 50%. Poor survival and high morbidity are driven by several perioperative factors. LÄS MER

5. 4. In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics

   Författare :Emmy Borgmästars; Malin Sund; Ola Billing; Pär Jonsson; Zelmina Lubovac-Pilav; Oskar Franklin; Stefan Enroth; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pancreatic cancer; microRNA functional analysis; TPS; miRNomics; metabolomics; proteomics; plasma samples; early detection; risk; survival;

   Sammanfattning : Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. LÄS MER

7. 5. Development of a targeted Drug Delivery System for treatment of Pancreatic Ductal Adenocarcinom

   Författare :Carlos Urey; Lund Kirurgi; []
   Nyckelord :Drug Delivery Systems; Liposomes; Pancreatic cancer;

   Sammanfattning : Pancreatic cancer is the fourth leading cause of cancer-related death with a 5-year survival of less than 6%. The only potential cure for pancreatic cancer is by surgical removal of the tumor. However, most patients present with an advanced and metastasized disease at the time of diagnosis, leaving only around 15% of patients eligible for surgery. LÄS MER