Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Drug Transport and Metabolism in Rat and Human Intestine

    Författare :Sofia Berggren; Hans Lennernäs; Janet Hoogstraate; Patrick Augustijns; Uppsala universitet; []
    Nyckelord :Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

    Sammanfattning : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. LÄS MER

  3. 2. Monitoring the cellular phosphate status in bloom-forming cyanobacteria of the Baltic Sea

    Författare :Sara Jonasson; Erik Söderbäck; Hans C. P. Matthjis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cyanobacteria; Baltic Sea; phosphorus; cyanotoxin; nodularin; Plant physiology; Växtfysiologi;

    Sammanfattning : In the Baltic Sea dense cyanobacterial blooms occur regularly during late summer. Since the dominant bloom-forming cyanobacteria, Nodularia spp. and Apanizomenon spp. are capable of fixing atmospheric dinitrogen, the macronutrient predominantly limiting their growth is phosphorus. LÄS MER

  4. 3. Exploratory clinical development of ropivacaine, a local anaesthetic, in ulcerative colitis

    Författare :Eva Arlander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug development; ulcerative colitis; ropivacaine; rectal administration; pharmacokinetics; metabolism.;

    Sammanfattning : The aims of this thesis were to explore the clinical pharmacology of ropivacaine gel as a potential new rectal therapy for ulcerative colitis (UC). The studies included pharmacokinetics, tolerability, preliminary efficacy in patients, formulation factors and drug-drug interactions. LÄS MER