Sökning: "PPARG"

Visar resultat 11 - 15 av 15 avhandlingar innehållade ordet PPARG.

  1. 11. Macrophage expression of VEGF and VEGFR-1. Potential involvement in atherogenesis

    Författare :Linda Salomonsson; Göteborgs universitet; []
    Nyckelord :atherosclerosis; macrophages; oxLDL; statins; VEGF; VEGFR-1;

    Sammanfattning : The vascular endothelial growth factor (VEGF) family is a group of proteins which contributes to both neovascularisation and inflammation. Elevated levels of VEGF have been found in subjects with atherosclerosis and correlate to several cardiovascular risk factors, e.g. hypertension and hyperlipidemia. LÄS MER

  3. 12. Cross-tissue regulatory gene networks in coronary atherosclerosis

    Författare :Husain Ahammad Talukdar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Coronary artery disease (CAD) is the underlying cause of myocardial infarction and stroke that together are responsible for nearly 30% of all global deaths. CAD is a common complex disease caused by the interactions of multiple genetic and environmental risk factors acting across several metabolic and vascular tissues. LÄS MER

  4. 13. A study on the role of T helper cells in allergic inflammation

    Författare :Julian Mario Stark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Asthma is a chronic inflammatory disease of the airways affecting hundreds of millions of people worldwide. Central to the development of asthma and allergic airway inflammation are CD4 T cells, which upon activation through their T cell antigen receptor, differentiate into T helper (Th) cells with the potential to secrete distinct sets of cytokines. LÄS MER

  5. 14. Type 2 Diabetes in a Defined Population The Skaraborg Hypertension and Diabetes Project

    Författare :Carl Johan Östgren; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; HOMA; primary care; all-cause mortality; Pro12Ala; PPAR-gamma; survival; insulin resistance; beta-cell function; type 2 diabetes; hypertension; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : To examine cardiovascular risk factors, glycaemic control and survival in patients with type 2 diabetes mellitus (T2DM) treated in primary care, patients with T2DM and a randomised age-stratified sample of men and women aged ≥40 years living in the same community were surveyed 1992-1994. ß–Cell function and insulin resistance were estimated using the Homeostasis Model Assessment (HOMA). LÄS MER

  7. 15. Gene x lifestyle interactions in type 2 diabetes mellitus and related traits

    Författare :Ema C Brito; Paul Franks; Aline Meirhaeghe; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene x environment interaction; gene x lifestyle interaction; physical activity; type 2 diabetes; European Youth Heart Study; Malmö Preventive Project; Prevalence and Prediction and Prevention of Diabetes in Botnia; PPARGC1A; CDKN2A B; HNF1B; TCF7L2; FTO; Epidemiology; Epidemiologi; epidemiologi; Epidemiology; genetik; Genetics;

    Sammanfattning :   Background: Type 2 diabetes is thought to result from interactions between genetic and lifestyle factors, but few robust examples exist. The overarching aim of this thesis was to discover such interactions by studying cohorts of white youth and adults from northern Europe in which physical activity, genotypes, and diabetes-related traits or diabetes incidence had been ascertained. LÄS MER