Sökning: "FTO"
Visar resultat 1 - 5 av 24 avhandlingar innehållade ordet FTO.
1. Obesity and Increased Susceptibility : Role of FTO and MGAT1 Genetic Variants
Sammanfattning : Obesity is a complex and a highly individualized disease and the molecular mechanisms behind this disorder need to be better elucidated. Identification of genes and genetic variants that are involved provide opportunities to establish a genetic understanding of the disease. LÄS MER
2. Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
Sammanfattning : Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on apolipoprotein E (APOE), fat mass and obesity-related (FTO) and ghrelin/obestatin prepropeptide (GHRL) genes, as well as smoking, physical activity and diet. LÄS MER
3. Bone health and nutrition treatment. Studies on young women with anorexia nervosa and children with epilepsy
Sammanfattning : Background: Adequate nutritional status is crucial for optimal longitudinal growth and accrual of bone mass during childhood and adolescence. Peak bone mass achieved in young adulthood affects bone health throughout life. LÄS MER
4. The role of genetics in regulation of weight loss and food intake
Sammanfattning : While obesity is a world leading health problem, the most efficient treatment option for severely obese patients is Roux-Y gastric bypass (RYGB) surgery. However, there are large inter-individual differences in weight loss after RYGB surgery. LÄS MER
5. Gene x lifestyle interactions in type 2 diabetes mellitus and related traits
Sammanfattning : Background: Type 2 diabetes is thought to result from interactions between genetic and lifestyle factors, but few robust examples exist. The overarching aim of this thesis was to discover such interactions by studying cohorts of white youth and adults from northern Europe in which physical activity, genotypes, and diabetes-related traits or diabetes incidence had been ascertained. LÄS MER