Sökning: "PPARγ"
Visar resultat 11 - 15 av 20 avhandlingar innehållade ordet PPARγ.
11. Further delineation of molecular alterations in adreno-medullary tumors
Sammanfattning : Pheochromocytomas, abdominal paragangliomas and neuroblastomas are tumors of the sympathetic nervous system. Anatomically pheochromocytomas and abdominal paragangliomas arise from sympathoadrenal paraganglia, within and outside the adrenal medulla, respectively. LÄS MER
12. Defining the Role of GGTase-I in the Development of Rheumatoid Arthritis and Atherosclerosis
Sammanfattning : RHO family proteins control cell movement and intracellular signaling by cycling between active GTP-bound and inactive GDP-bound states. Aberrant signaling of RHO GTPases has been implicated in many diseases including cancer and inflammation. LÄS MER
13. Novel biomarkers in regulating human dense connective tissue repair
Sammanfattning : Painful and degenerative disorders of the musculoskeletal system pose a tremendous burden on the healthcare system. One main reason is the limited knowledge of the underlying key factors and pathways responsible for the suboptimal and often varying healing outcomes of dense connective tissues (CTs), such as tendons, ligaments and knee meniscus, which have vital supportive, protective and force transmitting roles in the human body. LÄS MER
14. Inflammation and host-microbe signaling in the development and progression of colorectal carcinoma
Sammanfattning : Gut microbiota play an integral role in the postnatal development and maturation of the intestinal epithelium as well as the innate and adaptive immune system. Gut microbes communicate to the host via pattern recognition receptors (PRRs) which regulate intestinal homeostasis during health and disease. LÄS MER
15. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine
Sammanfattning : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. LÄS MER