Sökning: "PPARγ"

Visar resultat 6 - 10 av 20 avhandlingar innehållade ordet PPARγ.

  1. 6. On the importance of fat cell size, location and signaling in insulin resistance

    Författare :Niclas Franck; Fredrik Nyström; Torbjörn Lindström; Anna Krook; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Obesity has reached epidemic proportions worldwide and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. During the past decades, substantial evidence has demonstrated that not only the amount of adipose tissue constitutes a major determinant in the development of metabolic disorders, but also the distribution. LÄS MER

  3. 7. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. LÄS MER

  4. 8. Assessment of environmental contaminants’ neurotoxicity : in vitro and in vivo experimental studies

    Författare :Wan Norhamidah Wan Ibrahim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Accumulating evidence points to environmental contaminants as possible causes of neuronal damage in developing organisms. A prerequisite to prevention is the recognition of a chemical’s harmful effects during development. LÄS MER

  5. 9. Mammalian thioredoxin reductase 1 in antioxidant defense, regulation of adipocyte differentiation and as an anticancer drug target

    Författare :Xiaoxiao Peng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Reactive oxygen species (ROS) are oxygen containing reactive molecules generated as by-products of cellular metabolism. At physiological concentrations, ROS acts as secondary messengers in cellular signaling transduction, but excessive amounts of ROS result in oxidative stress and cellular damage. LÄS MER

  7. 10. Metabolic Significance of Fatty Acid Elongation

    Författare :Damir Zadravec; Anders Jacobsson; Douglas Tocher; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : Very long-chain fatty acids (VLCFAs), including polyunsaturated fatty acids (PUFAs), are essential lipids whose functional diversity is made possible by variation in their chain length and degree of unsaturation. Fatty acids can either be derived directly from the diet or they can be synthesized de novo through lipogenesis, up to 16 carbons in length by fatty acid synthase. LÄS MER