Sökning: "Neurosciences"

Visar resultat 41 - 45 av 672 avhandlingar innehållade ordet Neurosciences.

1. 41. Developing a Porcine Model to Study the Glymphatic System

   Författare :Nicholas Bechet; Glia-Immune Interactions; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glymphatic system; cerebrospinal fluid; Porcine; in vivo imaging; amyloid beta; Alzheimer disease;

   Sammanfattning : The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. LÄS MER

3. 42. Temporal events in neuronal differentiation and cell death : expression and processing of the Alzheimer's amyloid precursor protein family and a protein at the nuclear pore

   Författare :Marie Beckman; Kerstin Iverfeldt; David H. Small; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

   Sammanfattning : The present study had two major objectives: 1) to elucidate the involvement of Alzheimer’s amyloid precursor protein (APP) family in neuronal differentiation, and the effect of the Alzheimer’s disease (AD)-linked mutation APPV642I on signal transduction; 2) to investigate the fate of the nuclear pore complex protein POM121 during apoptosis and to examine the possibility of using green fluorescent protein (GFP)-labelled POM121 as a non-invasive sensor of apoptosis in living (non-fixed) cells.APP is the parent protein of the b-amyloid peptide, which is the major peptide constituent in the “senile plaques” of AD. LÄS MER

4. 43. Peripheral and Central Mechanisms in Irritable Bowel Syndrome : in search of links

   Författare :Olga Bednarska; Susanna Walter; Åsa Keita; Maria Engström; Magnus Ström; Asbjørn Mohr Drewes; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Irritable bowel syndrome (IBS) is a chronic visceral pain disorder with female predominance, characterized by recurrent abdominal pain and disturbed bowel habits in the absence of an identifiable organic cause. This prevalent and debilitating disease, which accounts for a substantial economic and individual burden, lacks exact diagnostic tools and effective treatment, since its pathophysiology remains uncertain. LÄS MER

5. 44. Untangling Cortico-Striatal Circuitry and its Role in Health and Disease - A computational investigation

   Författare :Jovana Belic; Jeanette Hellgren Kotaleski; Arvind Kumar; Abigail Morrison; Arthur Leblois; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortico-striatal circuits; levodopa-induced dyskinesia; Parkinson’s disease; effective connectivity; cross-frequency coupling; corticostriatal network; network oscillations; GABAergic transmission. basal ganglia; striatum; cortex; fast spiking interneurons; medium spiny neurons; neuronal avalanches;

   Sammanfattning : The basal ganglia (BG) play a critical role in a variety of regular motor and cognitive functions. Many brain diseases, such as Parkinson’s diseases, Huntington’s disease and dyskinesia, are directly related to malfunctions of the BG nuclei. LÄS MER

7. 45. Modelling driver steering and neuromuscular behaviour

   Författare :Ola Benderius; Chalmers tekniska högskola; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; reaching; neuromuscular behaviours; lateral control; driver models; Driver behaviours; active safety; autonomous vehicles;

   Sammanfattning : This thesis challenges the traditional view of treating steering behaviour as a tracking task, instead treating it as a reaching task. Here, reaching refers to a fundamental human behaviour with the the intriguing characteristic of having a linear relationship between maximum speed and distance, effectively making the movement time constant. LÄS MER