Sökning: "nicotine"

Visar resultat 1 - 5 av 110 avhandlingar innehållade ordet nicotine.

  1. 1. Neurotoxic Effects of Nicotine During Neonatal Brain Development : Critical Period and Adult Susceptibility

    Författare :Emma Ankarberg; Per Eriksson; Richard F. Seegal; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Biology; nicotine; neonatal development; behaviour; nicotinic receptors; susceptibility; cholinergic system; paraoxon; PBDE; Biologi; Biology; Biologi;

    Sammanfattning : This thesis examined neurotoxic effects of nicotine exposure during a defined critical period of neonatal brain development in mice.In our environment there are numerous hazardous contaminants that an individual can be exposed to during its entire lifetime. LÄS MER

  2. 2. Nicotine sensitization and loss of inhibitory control. Role of serotonin

    Författare :Peter Olausson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nicotine; Amphetamine; Locomotor activity; Inhibitory control; Dopamine; Serotonin; Sensitization; Nucleus accumbens; Elevated plus-maze;

    Sammanfattning : Drug dependence is a devastating disorder present in all parts of the world. It is manifested by craving and a general loss of control over the drug intake and the life situation, ultimately leading to compulsive use of the addictive drug at the expense of normal behavioral patterns. LÄS MER

  3. 3. Harm and harm reduction in smokeless tobacco users. An in vitro and clinical study

    Författare :Mats Wallström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cessation; nicotine replacement; smokeless tobacco; immunotoxicity; oral mucosa; snuff; reversibility; Langerhans cells; rat oral epithelium; nicotine;

    Sammanfattning : Background: This thesis describes the effects of smokeless tobacco (ST) and its derivatives on the oral mucosa; the development of, and results of applying a cessation program for snuff users with long and extensive exposure; and the persistent clinical and histomorphological changes after cessation. Methods: Three of the studies were open prospective non-randomized clinical intervention trials using nicotine replacement therapy (NRT) of either 4 mg nicotine chewing gum or 2 mg nicotine lozenges. LÄS MER

  4. 4. Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat

    Författare :Julia Morud; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abstinence; Dopamine; Elevated plus-maze; GABA; Inhibitory control; Nicotine; Nucleus accumbens; Sensitization;

    Sammanfattning : Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. LÄS MER

  5. 5. Role of environmental toxins in chronic experimental arthrithis - in search for anti-inflammatory pathways of ethanol and nicotine

    Författare :Sofia Silfverswärd Lindblad; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; collagen-induced arthritis; ethanol; testosterone; nuclear factor kappa B; smoking; nicotine; NMDA; regulatory T cells;

    Sammanfattning : Rheumatoid arthritis (RA) is a common systemic autoimmune disorder and a debilitating disease affecting 1% of the world population. The etiology of RA is an unresolved issue. Environmental factors such as alcohol intake and cigarette smoke have been described as contributing to the pathogenesis of RA. LÄS MER