Sökning: "NMDA receptor subunits"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden NMDA receptor subunits.

1. 1. Chemical and stimulus-induced NMDA-dependent plasticity and the possible involved mechanisms

   Författare :Rui Li; Göteborgs universitet; []
   Nyckelord :synaptic plasticity; hippocampus; LTP; LTD; AMPA; NMDA; NR2A; NR2B;

   Sammanfattning : Long-term potentiation (LTP) and long-term depression (LTD) are considered as the most important forms of synaptic plasticity involved in learning and memory. The traditional way to induce LTP and LTD is by electric stimulation leading to activation of NMDA-R. LÄS MER

3. 2. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration

   Författare :Marcus Petersson; Erik Fransén; Abdel El Manira; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transient receptor potential; TRP; metabotropic glutamate receptor; mGlu1 5; dendritic integration; synaptic activation; temporal summation; low-frequency; entorhinal cortex; mathematical model; computational neuroscience; Computer science; Datavetenskap;

   Sammanfattning : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. LÄS MER

4. 3. On the role of NMDA receptor subunits in the acute and chronic effects of nicotine

   Författare :Alexander Kosowski; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :PCR; microdialysis; Wistar;

   Sammanfattning : Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy with other drugs of abuse, nicotine enhances dopamine (DA) neurotransmission within the mesocorticolimbic DA system. LÄS MER

5. 4. Experimental studies of N-methyl-D-aspartate receptor NR3 subunits

   Författare :Anna Öhman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis focuses on the NR3A and NR3B subunits of the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). Functional NMDA receptors are believed to be tetrameric complexes with combinations of NR1 and NR2 subunits, and possible addition of NR3 subunits. LÄS MER

7. 5. NMDA receptors in neurodegeneration : studies on NMDA receptor subunit expression preceding ischemia-induced delayed nerve cell death

   Författare :Olof Bendel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : NMDA receptors are glutamate-gated ion channels that are permeable to Ca2+. NMDA receptors are tetramers formed by a combination of subunits. In the present thesis, we describe the novel NR3B subunit that we cloned in mouse and human. NR3B was found to be expressed in the adult rat and human central nervous system (CNS). LÄS MER