Sökning: "NLRP3"

Visar resultat 26 - 28 av 28 avhandlingar innehållade ordet NLRP3.

  1. 26. The interplay between lipoproteins, immunity and tryptophan metabolism in atherosclerosis

    Författare :Konstantinos A Polyzos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis is initiated by the infiltration and accumulation of low-density lipoprotein (LDL) cholesterol in the vascular wall, which activates the innate and adaptive arm of immunity, thereby causing chronic vascular inflammation. LÄS MER

  3. 27. Molecular determinants of disease severity in urinary tract infection

    Författare :Ines Ambite; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Asymptomatic bacteriuria; urinary tract infection; acute pyelonephritis; cystitis; Escherichia coli 83972; host response; NlpD; RNA Polymerase II; transcription regulation; inflammasome; Il-1β; ASC; NLRP-3; hyper-inflammatory disorder; MMP-7; IL-1RA; genetic susceptibility; IRF-7; siRNA therapy; P fimbriae; type 1 fimbriae;

    Sammanfattning : In the urinary tract, Escherichia coli infection may result in life-threatening disease, or asymptomatic bacterial carriage, comparable to bacterial commensalism in the gut. Pathogenic strains trigger a disease provoking host response which differs depending on the infected organ. LÄS MER

  4. 28. Inflammation and Intestinal Homeostasis-Associated Genes in Colorectal Cancer

    Författare :Jonas Ungerbäck; Peter Söderkvist; Martin Hallbeck; Kari Hemminki; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is a global ‘killer’ and every year more than 1.2 million new individuals are affected and approximately 600 000 succumb to the disorder. Several mechanisms such as inactivation of tumor suppressor genes, activation of oncogenes and dysregulation of cell fate determinating pathways e.g. LÄS MER