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Visar resultat 1 - 5 av 32 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

    Författare :Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). LÄS MER

  3. 2. Generalization under Model Mismatch and Distributed Learning

    Författare :Martin Hellkvist; Ayca Özcelikkale; Anders Ahlén; Martin Jaggi; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Machine learning; Signal processing; Generalization error; Training error; Double-descent; Double descent; Distributed learning; Distributed optimization; Learning over networks; Model mismatch; Model misspecification; Fake features; Missing features; linear regression; regularization; Machine learning; Maskininlärning;

    Sammanfattning : Machine learning models are typically configured by minimizing the training error over a given training dataset. On the other hand, the main objective is to obtain models that can generalize, i.e., perform well on data unseen during training. LÄS MER

  4. 3. Optimal Stopping and Model Robustness in Mathematical Finance

    Författare :Henrik Wanntorp; Johan Tysk; Svante Janson; Boualem Djehiche; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimal stopping; model robustness; American options; free boundary problems; hedging; option pricing; Mathematical statistics; Matematisk statistik;

    Sammanfattning : Optimal stopping and mathematical finance are intimately connected since the value of an American option is given as the solution to an optimal stopping problem. Such a problem can be viewed as a game in which we are trying to maximize an expected reward. LÄS MER

  5. 4. Some aspects of statistical inference in systems of equations

    Författare :Ghazi Shukur; Statistiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Statistics; small sample properties.; misspecification; system of equations; dynamic specification; operations research; programming; actuarial mathematics; Statistik; operationsanalys; programmering; aktuariematematik;

    Sammanfattning : The objective of this thesis is to develop a strategy for statistical/econometric inferences applicable to systemwise testing of econometric models. A common deficiency in many applied econometric studies is the absence of statistical diagnostic testing. LÄS MER

  7. 5. Learning about the unobservable : The role of attitudes, measurement errors, norms and perceptions in user behaviour

    Författare :Juan Manuel Lorenzo Varela; Yusak Susilo; R. Daniel Jonsson; Maria Börjesson; Soora Rasouli; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Attitudes; Measurement errors; Discrete choice analysis; Latent variables; Model misspecification; Normative beliefs; Rail factor; User perceptions; Social norms; Value of travel time savings; Transportvetenskap; Transport Science;

    Sammanfattning : Unobservable factors are important to understand user behaviour. Moreover, they contain information to help design services that willsolve today’s challenges. Yet, we have barely scratched the surface ofthe underlying mechanisms ruling user behaviour. LÄS MER