Sökning: "MDL"

Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet MDL.

  1. 6. Prevention of type 1 diabetes mellitus in experimental studies

    Författare :Maria Holstad; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. LÄS MER

  3. 7. Efficient Algorithms for Probabilistic Inference, Combinatorial Optimization and the Discovery of Causal Structure from Data

    Författare :Dag Wedelin; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In the first article we present a network based algorithm for probabilistic inference in an undirected structure. We show that the algorithm can be used as a general purpose approximation algorithm for combinatorial optimization, and discuss issues of approximation and convergence. LÄS MER

  4. 8. Serotonin in Fear and Anxiety

    Författare :S Melker Hagsäter; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; anxiety; fear; SSRI; IBS;

    Sammanfattning : That the neurotransmitter serotonin (5-HT) has a central role in fear and anxiety is supported by numerous experimental and clinical studies. Arguably the most illustrative example is the effect of serotonergic-acting drugs, and in particular the selective serotonin reuptake inhibitors (SSRIs), in the treatment of anxiety disorders. LÄS MER

  5. 9. Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus

    Författare :Lina Thorvaldson; Stellan Sandler; Michael Welsh; Maria Holstad; Maria Faresjö; Uppsala universitet; []
    Nyckelord :Cell biology; Cytokine; Diabetes; Tumor necrosis factor-α; Interferon-γ; Interleukin-4; Interleukin-10; Transplantation; Pancreatic islet; Glucose; Regulatory T cell; Cellbiologi;

    Sammanfattning : Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). This thesis studied the production of cytokines in experimental models of T1D and during transplantation of insulin-producing islets of Langerhans. LÄS MER

  7. 10. Development of positron emission tomography radioligands for the dopaminergic and serotonergic neurotransmission systems

    Författare :Camilla Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; Radioligand; Dopamine transporter; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor;

    Sammanfattning : The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to several neuropsychiatric disorders. The main objectives were to develop new suitable radioligands for positron emission tomography (PET) examinations of the dopamine transporter (DAT) as well as the serotonin 5-HT1A and 5-HT2A-receptors. LÄS MER