Sökning: "Pancreatic islet"

Visar resultat 1 - 5 av 181 avhandlingar innehållade orden Pancreatic islet.

  1. 1. Pancreatic Islet Transplantation : Modifications of Islet Properties to Improve Graft Survival

    Författare :Sanja Cabric; Olle Korsgren; Bo Nilsson; Peetra Magnusson; Michael Breimer; Uppsala universitet; []
    Nyckelord :Medicine; Diabetes; islet transplantation; islets of Langerhans; coagulation activation; IBMIR; hirudin; heparin; growth factor; angiogenesis; Medicin;

    Sammanfattning : During the past decade clinical islet transplantation has become a viable strategy for curing type 1 diabetes. The limited supply of organs, together with the requirement for islets from multiple donors to achieve insulin independence, has greatly limited the application of this approach. LÄS MER

  3. 2. The Microvasculature of Endogenous and Transplanted Pancreatic Islets : Blood Perfusion, Oxygenation and Islet Endocrine Function

    Författare :Richard Olsson; Per-Ola Carlsson; Leif Jansson; Arne Andersson; Thomas Linn; Uppsala universitet; []
    Nyckelord :Cell biology; diabetes mellitus; pancreatic islets; islet transplantation; vascular engraftment; islet microcirculation; oxygenation; blood flow; protein biosynthesis; Cellbiologi;

    Sammanfattning : Type 1 diabetes mellitus affects millions of people worldwide. Islet transplantation is a minimal invasive surgical procedure that restores euglycemia and halts the progression of diabetic complications. However, despite transplantation of islets from multiple donors most patients reverse to hyperglycemia within five years. LÄS MER

  4. 3. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease

    Författare :Sara Ullsten; Per-Ola Carlsson; Joey Lau; Sara Bohman; Rebecca L. Hull; Uppsala universitet; []
    Nyckelord :Pancreatic islets; heterogeneity; islet vascularity; blood flow; islet transplantation; islet amyloid; insulitis; type 1 diabetes; beta cell proliferation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. LÄS MER

  5. 4. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

    Författare :Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

    Sammanfattning : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. LÄS MER

  7. 5. Microencapsulation of Pancreatic Islets : A Non-Vascularised Transplantation Model

    Författare :Sara Bohman; Arne Andersson; Aileen King; Stellan Sandler; Eduard Montanya; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; Cell biology; Cellbiologi;

    Sammanfattning : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. LÄS MER