Sökning: "Lisa-Mari Nilsson"

Hittade 2 avhandlingar innehållade orden Lisa-Mari Nilsson.

1. 1. Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids

   Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholesterol; lipoproteins; bile acids; cholestyramine; chenodeoxycholic acid; CYP7A1; HNF4alpha; PCSK9; hepatocytes; ethanol; atherosclerosis; ApoE; thyroid hormone receptor;

   Sammanfattning : Excess plasma cholesterol, in particular high levels of LDL cholesterol, is a major risk factor for the development of atherosclerosis. The liver has a central role in the regulation of cholesterol metabolism: i) a major part of the cholesterol present in the body is synthesized in the liver; ii) the level of plasma lipoproteins is regulated by liver uptake and secretion of these particles and iii) the liver is essential for elimination of cholesterol from the body as such or by its conversion into bile acids. LÄS MER

3. 2. Studies on the molecular regulation of bile acids and lipoproteins in human liver

   Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only organ capable of a quantitative elimination of cholesterol from the body. LÄS MER