Sökning: "thyroid hormone receptor"

Visar resultat 1 - 5 av 56 avhandlingar innehållade orden thyroid hormone receptor.

  1. 1. In silico Identification of Thyroid Disrupting Chemicals : among industrial chemicals and household dust contaminants

    Författare :Jin Zhang; Patrik Andersson; A. Elisabeth Sauer-Eriksson; Liang-Hong Guo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thyroid disruption chemicals; virtual screening; tranthyretin; thyroid hormone receptor; QSAR modeling; molecular docking; molecular dynamics;

    Sammanfattning : Thyroid disruptions by xenobiotics have been associated with a broad spectrum of severe adverse human health effects, such as impaired brain development and metabolic syndrome. Ingestion of indoor dust and contact with industrial chemicals are two significant human exposure routes of thyroid hormone disrupting chemicals (THDCs), raising serious concerns for human health. LÄS MER

  3. 2. Life without thyroid hormone receptors

    Författare :Sten Göthe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thyroid hormone (TH) has many important functions during development and in the adult individual. It reaches its target cells via the blood system and binds its receptor (TR) located within the cell nucleus where the receptor regulates target genes. This hormone-mediated gene regulation is a finely tuned interplay of numerous parameters. LÄS MER

  4. 3. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    Författare :Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Sammanfattning : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. LÄS MER

  5. 4. Thyroid hormone receptors in liver metabolism

    Författare :Hjalmar Gullberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thyroid hormone has a profound impact on mammalian metabolism; hypothyroidism causes decreased metabolic rate and increased serum cholesterol levels. One major target organ for the hormone is the liver, the most important metabolic organ in mammals, that balances anabolism of carbohydrates and lipids against catabolism. LÄS MER

  7. 5. Recurrent unexplained first-trimester miscarriage. Effects of acetylcalicylic acid, platelet aggregation and thyroid disease

    Författare :Lennart Blomqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acetylsalicylic acid; recurrent miscarriage; platelet aggregation; pregnancy; early pregnancy; first-trimester; live birth; impedance aggregometry; thyroid stimulating hormone; levothyroxine; thyroid peroxidase antibody; arachidonic acid-induced platelet aggregation; platelet activators;

    Sammanfattning : Recurrent unexplained first-trimester miscarriage. Effects of acetylsalicylic acid, platelet aggregation and thyroid disease. Lennart Blomqvist, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden, 2019. LÄS MER