Sökning: "Lena Scott"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Lena Scott.

1. 1. Plasticity in the dopamine 1 receptor system : behavior and cell biological studies

   Författare :Lena Scott; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Plasticity; dopamine; D1R; NMDA; motor activity; spines;

   Sammanfattning : Dopamine is a key neurotransmitter in the brain, and has an important modulatory role in the control of motor activity and cognitive processes. Dysfunctions of the dopamine system have been implicated in several neuropsychiatric disorders such as schizophrenia and attention-deficit/hyperactivity disorder. LÄS MER

3. 2. Quantitative bioimaging in single cell signaling

   Författare :Kristoffer Bernhem; Hjalmar Brismar; Anita Aperia; Lena Scott; Christian Eggeling; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Super resolution imaging; fluoresence; bioimaging; cells; FRET; cluster analysis; labeling; image analysis.;

   Sammanfattning : Imaging of cellular samples has for several hundred years been a way for scientists to investigate biological systems. With the discovery of immunofluorescence labeling in the 1940’s and later genetic fluorescent protein labeling in the 1980’s the most important part in imaging, contrast and specificity, was drastically improved. LÄS MER

4. 3. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

   Författare :Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

   Sammanfattning : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. LÄS MER

5. 4. High-resolution Imaging of Cleared and Expanded Kidney Tissue Samples

   Författare :David Unnersjö Jess; Hans Blom; Hjalmar Brismar; Lena Scott; Karlhans Endlich; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kidney; Renal Pathology; Microscopy; Super-resolution microscopy; Tissue expansion; Foot processes; Glomerular filtration; Podocytes; Biological Physics; Biologisk fysik;

   Sammanfattning : The kidney is one of the most important and complex organs in the humanbody with the task of filtering hundreds of litres of blood daily. It is responsiblefor the salt and acid/base balance in the body, as well as secretinghormones important for red blood cell production and blood pressure regulation. LÄS MER

7. 5. Studies on the Role of Apoptosis in Kidney Diseases

   Författare :Linnéa Nilsson; Hjalmar Brismar; Anita Aperia; Lena Scott; Fredrik Palm; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; diabetic kidney disease; hyperglycemia; mesangial cells; microscopy; ouabain; podocytes; proximal tubule cells; RNA-seq; SGLT; Apoptos; diabetisk njursjukdom; hyperglykemi; mesangiala celler; mikroskopi; ouabain; podocyter; proximala tubuli celler; RNA-seq; SGLT; Biological Physics; Biologisk fysik;

   Sammanfattning : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. LÄS MER