Sökning: "bicelles"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet bicelles.

  1. 1. One key to two doors : Dual targeting peptides and membrane mimetics

    Författare :Weihua Ye; Lena Mäler; Göran Kalsson; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; : Dual targeting peptides; protein import; mitochondria and chloroplasts; bicelles; galactolipids; NMR spectroscopy; Biophysics; biofysik;

    Sammanfattning : A targeting peptide at the N-terminus of a precursor protein usually directs the protein synthesized in the cytosol to a specific organelle in the cell. Interestingly, some targeting peptides, so-called dual targeting peptides (dTPs) can target their protein to both mitochondria and chloroplasts. LÄS MER

  2. 2. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

    Författare :Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

    Sammanfattning : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. LÄS MER

  3. 3. Biophysical studies of cell-penetrating peptides and of the RNR inhibitor Sml1

    Författare :Elsa Bárány-Wallje; Astrid Gräslund; Joachim Seelig; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; transportan; bicelles; Sml1; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Several short peptides, so called cell-penetrating peptides, have the capability to transport large hydrophilic cargos through the cell membrane. The objective is to use these peptides as drug carriers and thereby enhance the uptake of drugs into cells.Three different cell-penetrating peptides are characterized in this thesis. LÄS MER

  4. 4. Biophysical studies of membrane associated peptides

    Författare :Jesper Lind; Astrid Gräslund; Lena Mäler; Christian Griesinger; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NMR; spectroscopy; membrane interaction; bicelles; Chemistry; Kemi; Biophysics; biofysik;

    Sammanfattning : A large part of the processes in living organisms involves proteins acting in a biological membrane. Biophysical studies on isolated model systems can give important understandings of the complicated biological mechanisms in the membrane. In this thesis peptide membrane interaction mechanisms are studied in several different systems. LÄS MER

  5. 5. Development of Surface-Based Methods for Studies of Non-Electrolyte Membrane Transport

    Författare :Seyed Tabaei; Chalmers University of Technology; []
    Nyckelord :membrane junction; surface plasmon resonance; membrane transfer; supported lipid bilayer; quartz crystal microbalance; aquaporin; bicelles; fluorescence microscopy;

    Sammanfattning : Membrane-transport proteins are a diverse family of proteins that all span the cell membrane where they control the transfer of nutrients, metabolites and ions into and out of the cell. Due to their vital role for the function of cells, reliable methods, preferably with high-throughput capacity, to study this class of proteins are essential in fundamental studies as well as in discovery and development of new drugs. LÄS MER