Sökning: "D1R"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet D1R.

  1. 1. Plasticity of the dopamine1 receptor and its signaling pathway

    Författare :Maria Sol Kruse; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine; D1R; trafficking; signaling pathway; NMDA;

    Sammanfattning : Dopamine 1 receptor (D1R) belongs to the G protein coupled receptor superfamily with seven transmembrane domains. Previous studies from our laboratory showed that D1R availability in the plasma membrane of renal epithelial cells is dynamically regulated by the dopaminergic tonus. Here, we *examined the availability of D1R in the brain. LÄS MER

  3. 2. Plasticity in the dopamine 1 receptor system : behavior and cell biological studies

    Författare :Lena Scott; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasticity; dopamine; D1R; NMDA; motor activity; spines;

    Sammanfattning : Dopamine is a key neurotransmitter in the brain, and has an important modulatory role in the control of motor activity and cognitive processes. Dysfunctions of the dopamine system have been implicated in several neuropsychiatric disorders such as schizophrenia and attention-deficit/hyperactivity disorder. LÄS MER

  4. 3. Positron emission tomography studies of the D1-dopamine receptor in schizophrenia

    Författare :Per Stenkrona; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis is based on investigations of central D1-dopamine receptor (D1R) binding in vivo using positron emission tomography (PET). The aims were i) to examine the antipsychotic effect of a D1R antagonist in schizophrenia and ii) to test the dopamine hypothesis of schizophrenia by comparing D1R binding between patients and healthy subjects. LÄS MER

  5. 4. Mathematical Models in Cellular Biophysics

    Författare :Jacob Kowalewski; Hjalmar Brismar; Erik Fransén; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Calcium oscillations; Diffusion; Dopamine receptors; Mathematical models; Computer simulations; FRAP; Physics; Fysik;

    Sammanfattning : Cellular biophysics deals with, among other things, transport processes within cells. This thesis presents two studies where mathematical models have been used to explain how two of these processes occur. Cellular membranes separate cells from their exterior environment and also divide a cell into several subcellular regions. LÄS MER

  7. 5. Striatal signaling in the treatment of Parkinson's disease

    Författare :Irene Sebastianutto; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Parkinson’s disease (PD) is a neurodegenerative disorder characterized by typical motor symptoms that are caused by depletion of dopamine (DA) in the striatum. These symptoms are treated with the DA precursor L-DOPA, or with DA receptor (DAR) agonists. LÄS MER