Sökning: "Lc3"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet Lc3.

  1. 1. Protein expression and modifications in denervated atrophic and hypertrophic skeletal muscle

    Författare :Kim Evertsson; Sven Tågerud; Håkan Westerblad; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeletal muscle; denervation; atrophy; hypertrophy; protein expression; protein phosphorylation; Akt; p38; MK2; Hsp25; Hsp70; FoxO1; MuRF1; autophagy; Lamp1; Lc3; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : Skeletal muscle comprises about 45% of the total body weight. It is the largest tissue in the body, vital for maintaining posture, produce locomotion, breathing but also functions as a large reservoir of proteins. LÄS MER

  3. 2. Modulation of PDGF receptors function by posttranslational modifications

    Författare :Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER

  4. 3. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease

    Författare :Andrea Boman; Katarina Kågedal; Samuel Svensson; Alan Sabirsh; Per Svenningsson; Oskar Hansson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrospinal fluid CSF ; biomarkers; therapeutic targets; neurodegeneration; Alzheimer’s disease AD ; Parkinson’s disease PD ; Corticobasal degeneration CBD ; Progressive supraneuclear palsy PSP ; Lysosomes; Endosomes; Autophagy; LAMP-2; Lysozyme;

    Sammanfattning : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. LÄS MER

  5. 4. The role of autophagy in anticancer therapy

    Författare :Matheus Dyczynski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. LÄS MER

  7. 5. Autophagy in Peripheral Neuropathy

    Författare :Ayman Osman; Simin Mohseni; Lars-Göran Dahlin; David Engblom; Maria V Turkina; Kaj Fried; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Peripheral neuropathy includes a wide range of diseases affecting millions around the world, and many of these diseases have unknown etiology. Peripheral neuropathy in diabetes represents a large proportion of peripheral neuropathies. Nerve damage can also be caused by trauma. LÄS MER