Sökning: "DUB"
Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet DUB.
1. Modulation of PDGF receptors function by posttranslational modifications
Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER
2. Potential New Drugs in Lymphoma
Sammanfattning : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). LÄS MER
3. Modulation of the deubiquitinating system in viral infection, lymphoid cell activation and malignant transformation
Sammanfattning : Most cellular proteins are affected by the conjugation of Ubiquitin (Ub), which may regulate their stability, activity or localization. The family of deubiquitinating enzymes (DUBs) removes Ub from conjugates and regulates the production and recycling of Ub. LÄS MER
4. A Passage to Organization
Sammanfattning : How does action turn [into a] substantive and, if it does, how does it turn into action again to perdure or even change?In this endeavor I set out to study organizing and organization by asking myself how organizing becomes a product called organization and how that product turns into the very organizing whence it once was spawned. In other words, I set out to study what I denominate the movements between organizing and organization. LÄS MER
5. Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy
Sammanfattning : The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, cell death, and cell cycle regulation. In comparison to cells in healthy tissues, cancer cells proliferate faster and have increased protein synthesis rate; therefore in order to preserve cellular fitness they are more dependent on UPS than normal cells. LÄS MER