Sökning: "Endosomes"

Visar resultat 1 - 5 av 42 avhandlingar innehållade ordet Endosomes.

1. 1. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease

   Författare :Andrea Boman; Katarina Kågedal; Samuel Svensson; Alan Sabirsh; Per Svenningsson; Oskar Hansson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrospinal fluid CSF ; biomarkers; therapeutic targets; neurodegeneration; Alzheimer’s disease AD ; Parkinson’s disease PD ; Corticobasal degeneration CBD ; Progressive supraneuclear palsy PSP ; Lysosomes; Endosomes; Autophagy; LAMP-2; Lysozyme;

   Sammanfattning : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. LÄS MER

3. 2. The synaptic and neurobiological role of apolipoprotein E4 in models of Alzheimer's disease

   Författare :Sabine Konings; Experimentell demensforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apolipoprotein E4; Alzheimer s Disease; Synapses; Endosomes; β-amyloid; Neurons; Astrocytes;

   Sammanfattning : .... LÄS MER

4. 3. Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans

   Författare :Yani Zhao; Andrea Hinas; Staffan Svärd; Simon Tuck; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; late endosomes MVBs; SID-5; SEC-22; SYX-6; C12D8.1; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The membrane system of a eukaryotic cell is a large and complex system handling the transport, exchange and degradation of many kinds of material. Recent research shows that double-stranded RNA (dsRNA) mediated gene silencing (RNA interference) is a membrane related process. LÄS MER

5. 4. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans

   Författare :Benjamin T. Holmgren; Andrea Hinas; Gerhart Wagner; Peter Brodersen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; Endomembrane system; Late endosome; SID-5; SEC-22; SYX-6; C12D8.1; RNA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. LÄS MER

7. 5. Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis

   Författare :Martha-Lena Müller; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined how certain missense mutations in genes encoding syntaxin-11 and Munc18-2 abolish exocytosis and cause disease. LÄS MER