Sökning: "SQSTM1 p62"
Hittade 4 avhandlingar innehållade orden SQSTM1 p62.
1. Modulation of PDGF receptors function by posttranslational modifications
Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER
2. Metabolic disorders : genes and mechanisms
Sammanfattning : Mitochondrial disorders constitute a subgroup of the large family of rare monogenic diseases called Inborn Errors of Metabolism (IEM), but defects in mitochondrial activity have also been reported in more common and complex pathologies. In the present thesis, I validate new disease-causing variants and study the underlying molecular defects in three different cases of IEM. LÄS MER
3. Regulation of cellular degradation pathways by viral oncoproteins and microRNAs
Sammanfattning : The cellular degradation system actively participates in cell homeostasis. Despite ongoing efforts and much progress in recent years, the underlying mechanisms of these pathways are not entirely understood. LÄS MER
4. Systems biology of mitochondrial dysfunction
Sammanfattning : The human body consumes vast amounts of metabolites that are transformed into one another, modified to useful building blocks and broken down to harvest their energy. Mitochondria are at the core of this metabolic turnover and oxidative phosphorylation provides most cellular ATP in almost all human tissues. LÄS MER
