Sökning: "LIGANDS"

Visar resultat 6 - 10 av 934 avhandlingar innehållade ordet LIGANDS.

  1. 6. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

    Författare :Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. LÄS MER

  3. 7. Characterization of Diagnostic Tools and Potential Treatments for Alzheimer’s Disease : PET ligands and BACE1 inhibitors

    Författare :Fredrik Jeppsson; Anna-Lena Ström; Kerstin Iverfeldt; Samuel Svensson; Martin Hallbeck; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer’s disease; Diagnostics; Treatment; PET ligand; BACE1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Alzheimer’s disease (AD) is a very complex disorder and the most common form of dementia. The two pathological hallmarks of AD are extracellular amyloid-β (Aβ) plaques in cerebral cortex, and intraneuronal neurofibrillary tangles. LÄS MER

  4. 8. Atom Probe Tomography Investigations of Biologically Relevant Nanoparticles

    Författare :Gustav Eriksson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; surface modification; Nanoparticles; silica; hydroxyapatite; electron microscopy; ligands; atom probe tomography; titanium;

    Sammanfattning : The study of materials at the nanoscale is essential in many scientific disciplines. For example, in materials science the size of the building blocks of a material is directly linked to its properties. LÄS MER

  5. 9. Modulation of Receptor Signaling and Functional Selectivity in Neutrophils

    Författare :Michael Gabl; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; G-protein coupled receptors; reactive oxygen species; ligands; functional selectivity; allosteric modulation;

    Sammanfattning : Neutrophils are important effector cells of the innate immune system and in the regulation of inflammation. Many of their functions, such as chemotactic migration, secretion of granule constituents and activation of the oxygen radical-producing NADPH-oxidase, are regulated by cell surface receptors. LÄS MER

  7. 10. Activation of CO2 by Palladium Complexes Bearing Tridentate PCP Ligands

    Författare :Roger Johansson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metallorganisk kemi; Organometallic chemistry; Kinetics; Insertion reactions; PCP ligands; CO2 activation; Palladium II complexes;

    Sammanfattning : The present thesis deals with the activation of CO2 by insertion reactions into palladium-carbon bonds. This has been realised for the complexes {2,6-bis[(di-t-butylphosphino)methyl]benzene}palladium(II)methyl [(PCP)PdMe] and (PCP)PdCH2CHCH2. These complexes have also been used in the catalytic carboxylation of ZnMe2 and Bu3SnCH2CHCH2. LÄS MER