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Visar resultat 11 - 15 av 21 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. Notch Signaling in Neuroblastoma and Renal Cell Carcinoma

    Författare :Jonas Sjölund; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; differentiation; clear cell renal cell carcinoma; neuroblastoma; TGF-beta; migration; γ-secretase; valproic acid; cancer; Notch; ERK; von Hippel-Lindau; hypoxia;

    Sammanfattning : The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. LÄS MER

  3. 12. Modulation of Adenovirus E1A Activities by the Cellular Corepressor CtBP

    Författare :Cecilia Johansson; Catharina Svensson; Laszlo Szekely; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Adenovirus; E1A; CtBP; transcription regulation; TetON; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Adenovirus E1A is needed to activate early viral genes and induce cell cycle progression to optimise the conditions for viral replication. This is mostly achieved through interactions between the first exon of E1A and cellular transcriptional regulatory proteins. LÄS MER

  4. 13. HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?

    Författare :Atosa Estekizadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented in several cancer types. LÄS MER

  5. 14. Expression and activity of Myc network proteins during cell cycle progression and differentiation

    Författare :Nikita Popov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transcription factors of Myc network are the key regulators of cell proliferation, cell death and differentiation. Identified as a transforming oncogene, myc is the driving force of a variety of human cancers, and inactivation of myc in tumors can cause their rapid regression. LÄS MER

  7. 15. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Författare :Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Nyckelord :Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Sammanfattning : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. LÄS MER