Sökning: "TetON"

Hittade 3 avhandlingar innehållade ordet TetON.

  1. 1. Modulation of Adenovirus E1A Activities by the Cellular Corepressor CtBP

    Författare :Cecilia Johansson; Catharina Svensson; Laszlo Szekely; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Adenovirus; E1A; CtBP; transcription regulation; TetON; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Adenovirus E1A is needed to activate early viral genes and induce cell cycle progression to optimise the conditions for viral replication. This is mostly achieved through interactions between the first exon of E1A and cellular transcriptional regulatory proteins. LÄS MER

  3. 2. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies

    Författare :Sara Bolin; Fredrik Swartling; Martine F. Roussel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Recurrence; MYC; SOX9; FBW7; Treatment; BET bromodomains; Cyclin-dependent kinases; Oncology; Onkologi;

    Sammanfattning : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. LÄS MER

  4. 3. The Role of SOX9 in Medulloblastoma

    Författare :Vasil Savov; Fredrik Swartling; Ulrich Schüller; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; SOX9; MYCN; cancer development; recurrence; regulation; tumor metastasis; migration; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Overall survival is about 70% and in cases where current treatment fails, the disease recurs and most often is fatal. At the molecular level, MB can be divided into four defined subgroups: WNT, SHH, Group 3 and Group 4. LÄS MER