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Visar resultat 16 - 20 av 299 avhandlingar som matchar ovanstående sökkriterier.

1. 16. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

   Författare :Britt Losman; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

   Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

3. 17. Studies on HIV-1 core assembly

   Författare :Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

   Sammanfattning : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. LÄS MER

4. 18. Plant-produced STI vaccine antigens with special emphasis on HIV-1 p24

   Författare :Ingrid Lindh; Åke Strid; Sören Andersson; Edward Rybicki; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Plant-based vaccines; Arabidopsis thaliana; HIV-1; p24; GALT; mucosal immunity; Chlamydia trachomatis; MOMP; Daucus carota; Chemistry; Kemi; Chemistry; Kemi;

   Sammanfattning : Objective: To establish stable transgenic non-toxic plants as a platform for plant-based vaccine production as well as potential oral delivery system of vaccine antigens for sexually transmitted infections (STIs). The concept is to immunize the mucosal immune system present in the gut-associated lymphoid tissues (GALT). LÄS MER

5. 19. Altering HIV-1 envelope glycoprotein maturation and its effects on viral infectivity

   Författare :Alenka Jejcic; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1;

   Sammanfattning : HIV-1 is dependent on its envelope glycoprotein (Env) to initiate infection. Env binds to cellular receptors and mediate the following fusion of the viral envelope with the cell plasma membrane. LÄS MER

7. 20. Antiretroviral treatment of HIV-1 in Sweden with focus on virological aspects

   Författare :Erik Sörstedt; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; antiretroviral therapy; transient viremia; viral blip; nucleoside transcriptase inhibitor resistance; dolutegravir; baseline viral load; HIV RNA; virological failure;

   Sammanfattning : From a clinical standpoint, there are many factors to consider when optimizing the care for people living with HIV (PLWH). With help from clinical guidelines, most obstacles can be addressed. Expanded knowledge is however in constant demand, from local conditions to universal processes. LÄS MER