Sökning: "V3-region"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet V3-region.

1. 1. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

   Författare :Britt Losman; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

   Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

3. 2. Functional studies on the interaction of immunoglobulins with HIV-2 envelope

   Författare :Samer Sourial; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV; Glycoprotein; Antibodies lgA IgG; V3; CD4; Neutralization; Immunization;

   Sammanfattning : Infection with HIV-2 has a much more limited geographic distribution than HIV-1, being less readily transmitted and is generally less pathogenic. The role of immunoglobulins in defence against pathogens in different body compartments is known, where IgG is the principal isotype in the blood and extracellular fluid while lgA predominates in the mucosal compartment. LÄS MER

4. 3. Factors influencing the evolution of HIV-1

   Författare :Markus Birk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV; antiretroviral treatment; evolution; gag; pol; env;

   Sammanfattning : Due to the high replication rate and the low fidelity of the viral reverse transcriptase (RT), various mutations are introduced continuously into the gene pool of HIV-1. Together with recombination events this leads to the evolution of countless quasispecies. LÄS MER

5. 4. Approaches to modulate vaccine-induced antibody responses

   Författare :Martina Soldemo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Most successful licensed vaccines mediate protection by inducing antibody responses capable of protecting the individual from infection or disease. Despite the availability of many effective vaccines, we lack knowledge about fundamental aspects of B cell immunity and how we respond to complex real-world protein antigens. LÄS MER

7. 5. Genotypic and serotypic characterization of HIV in Ethiopia

   Författare :Kimdar Sherefa Kemal; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; V3; serotype; genotype; recombination;

   Sammanfattning : The human immunodeficiency virus type I (HIV-1) is characterized by a high genomic heterogeneity. Different subtypes and inter-subtype recombinants have been identified in the HIV pandemic. The most precise and widely used method for subtype classification is based on molecular biology techniques; nucleotide sequencing of partial genomic fragments. LÄS MER