Sökning: "Samir Abdurahman"

Hittade 2 avhandlingar innehållade orden Samir Abdurahman.

1. 1. Mechanisms on HIV-1 core assembly

   Författare :Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER

3. 2. Studies on HIV-1 core assembly

   Författare :Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

   Sammanfattning : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. LÄS MER