Sökning: "capsid assembly"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden capsid assembly.

1. 1. Control of Quasi-Equivalence in Virus Capsids

   Författare :Charlotte Helgstrand; B. V. Venkataram Prasad; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; crystallography; bacteriophage; virus; RNA; capsid; quasi-equivalence; assembly; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Many T=3 plant and insect viruses use a molecular switch in form of order/disorder of a segment of the polypeptide chain to regulate the quasi-equivalent contacts. The structure of a mutant of the T=3 capsid of bacteriophage fr confirms that this virus and other members of the Leviviridae family lack a switch mechanism. LÄS MER

3. 2. Studies on HIV-1 core assembly

   Författare :Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

   Sammanfattning : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. LÄS MER

4. 3. Protein interactions involved in alphavirus assembly

   Författare :Ulrica Skoging Nyberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alphavirus; Semliki Forest Virus; Virus assembly; Capsid Protein; Nucleocapsid; Viral Envelope Proteins;

   Sammanfattning : Viruses have to protect their genomes during transport from the infected to an uninfected host cell. This is achieved by forming a protein shell around the nucleic acid. Virus assembly is a complex process that involves interactions with the viral genome, the viral structural proteins and for enveloped viruses a lipid membrane. LÄS MER

5. 4. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

   Författare :Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

   Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER

7. 5. The role of the capsid protein in Semliki Forest virus assembly

   Författare :Kerstin Forsell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Semliki Forest virus; RNA encapsidation; NC assembly; virus budding; RNA uncoating;

   Sammanfattning : Enveloped viruses, like the Alphaviruses, encapsidate their genomes into a nucleocapsid (NC) or core structure which is surrounded by a lipid bilayer (envelope) with spike proteins. The alphavirus Semliki Forest virus (SFV), is an RNA virus with a genomic 42 S RNA of positive polarity. LÄS MER