Sökning: "Gene Frequency"
Visar resultat 16 - 20 av 383 avhandlingar innehållade orden Gene Frequency.
16. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
Sammanfattning : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. LÄS MER
17. Studies on genetic and epigenetic regulation of gene expression dynamics
Sammanfattning : The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes cellular functional diversity and dysregulation of transcription is a central tenet of human disease. LÄS MER
18. Genetic variation in structured populations
Sammanfattning : It is widely acknowledged that the process of speciation in the presence of gene flow between different ecotypes is common in nature. However, the mechanisms underlying speciation are not understood. LÄS MER
19. Adoption studies on psychiatric illness : epidemiological, environmental and genetic aspects
Sammanfattning : The aim of this study is to evaluate the outcome of adoptions and to study the gene-environment influences on psychiatric illness as well as sick-leave patterns. The material consists of 2 966 adopted persons born between 1917 and 1949, their 5 932 adoptive parents and 5 438 identified biological parents. LÄS MER
20. An integrative strategy for targeted evaluation of biomarker expression in non-small cell lung cancer
Sammanfattning : Despite improvements in therapy, the prognosis for non-small cell lung cancer (NSCLC) patients remains poor, and cure is only possible in localized tumors after surgical resection. A new generation of targeted cancer drugs has led to the expectation that lung cancer therapy can be significantly improved, but these drugs are today only an option in a small subset of NSCLC patients, and their effect is temporary. LÄS MER