Sökning: "Degenerative disease"

Visar resultat 6 - 10 av 83 avhandlingar innehållade orden Degenerative disease.

1. 6. In search of lost disease : Clinical, qualitative and imaging studies to investigate long-term effects of autologous haematopoietic stem cell transplantation for multiple sclerosis

   Författare :Andreas Tolf; Joachim Burman; Anne-Marie Landtblom; Tobias Granberg; Laura Airas; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; Neurologi;

   Sammanfattning : With the introduction of autologous haematopoietic stem cell transplantation (AHSCT) for the treatment of multiple sclerosis (MS), there are now individuals living without experiencing disease activity of MS. Are they cured? There is a need for terminology to describe the state of these individuals. LÄS MER

3. 7. Degenerative cervical myelopathy: Surgical treatment, imaging evaluation, and outcome

   Författare :Eddie de Dios Perez; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical spondylotic myelopathy; decompression and fusion; degenerative cervical myelopathy; EMS; muscle-preserving laminectomy; MRI; P-mJOA; sagittal alignment; surgical outcome;

   Sammanfattning : Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord impairment in adults worldwide. The overall aims of this thesis were to compare patient-reported clinical outcomes, adverse events, and cost-effectiveness between decompression alone and decompression with fusion; evaluate magnetic resonance imaging (MRI)-based sagittal alignment measurements; determine postoperative improvement rates and potential predictors of surgical outcome; and compare the patient-derived modified Japanese Orthopaedic Association (P-mJOA) scale with the European Myelopathy Score (EMS) for the assessment of DCM. LÄS MER

4. 8. Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain

   Författare :Carina Sihlbom; Göteborgs universitet; []
   Nyckelord :glycoproteomics; quantitative proteomics; glycoprotein; protein quantification; glycosylation; Fourier transform ion cyclotron mass spectrometry; cerebrospinal fluid; Alzheimer s disease; neurodegeneration; neuroregeneration; hippocampus; astrocytes; brain injury; 14-3-3 protein; isoform;

   Sammanfattning : Biological processes involve changes at the protein level. Proteomics aims to determine protein changes from a normal state, to measure for instance recovery or disease progression. Mass spectrometry is the most important tool for identification of proteins and determination of post-translational modifications such as glycosylation. LÄS MER

5. 9. Signs of inflammation in different types of heart valve disease : The VOCIN study

   Författare :Lars Wallby; Lena Jonasson; Mats Broqvist; Mårten Rosenqvist; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart valve dysfunction; heart valve disease; VOCIN study group; aortic valves; Gross valvular pathology; Cariology; Cariologi;

   Sammanfattning : Heart valve dysfunction is a relatively common condition in the population, whereas significant heart valve disease is more unusual. The cause of different types of heart valve disease depends on which valve is concerned. Rheumatic heart valve disease, has for a long time been considered to constitute a post-inflammatory condition. LÄS MER

7. 10. Novel Materials and Implant Designs for the Treatment of Degenerative Disc Disease

   Författare :Salim Ghandour; Cecilia Persson; Donal McNally; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Topology Optimization; Spine; Intervertebral Disc; Papain; Additive Manufacturing; Biomechanics; Bone Cement; PMMA; Calcium Phosphate; Cage; Fusion; Engineering Science with specialization in Biomedical Engineering; Teknisk fysik med inriktning mot medicinsk teknik;

   Sammanfattning : The overarching objective of this thesis was to develop intervertebral implants for degenerated discs through design, fabrication, and mechanical validation. The research had four primary aims, each addressing different facets of implant development. LÄS MER